Pub. Date : 2018 Feb 19
PMID : 29287722
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson"s disease through stabilizing PINK1 protein. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | nuclear paraspeckle assembly transcript 1 (non-protein coding) | Mus musculus |
| 2 | The expressions of NEAT1, PINK1 protein and LC3-II/LC3-I level were increased by MPTP in vitro and in vivo. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | nuclear paraspeckle assembly transcript 1 (non-protein coding) | Mus musculus |
| 3 | The results of in vivo experiments revealed that NEAT1 knockdown could effectively suppress MPTP-induced autophagy in vivo that alleviated dopaminergic neuronal injury. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | nuclear paraspeckle assembly transcript 1 (non-protein coding) | Mus musculus |
| 4 | CONCLUSION: LncRNA NEAT1 promoted the MPTP-induced autophagy in PD through stabilization of PINK1 protein. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | nuclear paraspeckle assembly transcript 1 (non-protein coding) | Mus musculus |