Title : Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line.

Pub. Date : 2017 Dec 28

PMID : 29282029






2 Functional Relationships(s)
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1 The DHA-induced decrease in FASN expression resulted from reduced pAkt/Akt signaling and not pERK1/2/ERK1/2 signaling. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
2 However, addition of rapamycin, an inhibitor of the mTOR signaling pathways, 1 h before addition of estradiol or insulin increased the pAkt/Akt ratio and FASN expression, and this effect was inhibited by addition of DHA 48 h before rapamycin. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens