Title : Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Pub. Date : 2018 Feb 2

PMID : 29279301






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 IP5 reinstates the interaction of HIF-1alpha and pVHL. 1D-myo-inositol 1,2,3,4,5-pentakisphosphate von Hippel-Lindau tumor suppressor Mus musculus
2 IP5 promotes HIF-1alpha prolyl hydroxylation and thus pVHL-dependent degradation of HIF-1alpha. 1D-myo-inositol 1,2,3,4,5-pentakisphosphate von Hippel-Lindau tumor suppressor Mus musculus
3 IP5 acts by enhancing HIF-1alpha hydroxylation and thus pVHL-dependent degradation of HIF-1alpha. 1D-myo-inositol 1,2,3,4,5-pentakisphosphate von Hippel-Lindau tumor suppressor Mus musculus