Title : Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Pub. Date : 2018 Feb 2

PMID : 29279301






3 Functional Relationships(s)
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1 RATIONALE: Inositol polyphosphate multikinase (IPMK) and its major product inositol pentakisphosphate (IP5) regulate a variety of cellular functions, but their role in vascular biology remains unexplored. 1D-myo-inositol 1,2,3,4,5-pentakisphosphate inositol polyphosphate multikinase Mus musculus
2 RATIONALE: Inositol polyphosphate multikinase (IPMK) and its major product inositol pentakisphosphate (IP5) regulate a variety of cellular functions, but their role in vascular biology remains unexplored. 1D-myo-inositol 1,2,3,4,5-pentakisphosphate inositol polyphosphate multikinase Mus musculus
3 CONCLUSIONS: IPMK, via its product IP5, negatively regulates angiogenesis by inhibiting VEGF expression. 1D-myo-inositol 1,2,3,4,5-pentakisphosphate inositol polyphosphate multikinase Mus musculus