Title : Testosterone Diminishes Cabazitaxel Efficacy and Intratumoral Accumulation in a Prostate Cancer Xenograft Model.

Pub. Date : 2018 Jan

PMID : 29276148






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inactivation of the androgen receptor (AR) pathway by androgen deprivation therapy (ADT) is the mainstay of (metastatic) prostate cancer therapy. adt androgen receptor Homo sapiens
2 Inactivation of the androgen receptor (AR) pathway by androgen deprivation therapy (ADT) is the mainstay of (metastatic) prostate cancer therapy. adt androgen receptor Homo sapiens
3 The recent STAMPEDE and CHAARTED trials showed that docetaxel in combination with ADT increased survival in hormone sensitive prostate cancer patients, suggesting cross-talk between AR signaling and chemotherapy efficacy. adt androgen receptor Homo sapiens