Title : In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Pub. Date : 2018 Feb 8

PMID : 29271657






1 Functional Relationships(s)
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1 Cocrystallization of one inhibitor, which shows potentiation of Meropenem activity against MBL-expressing Enterobacteriaceae, with VIM-2 reveals an unexpected binding mode, involving interactions with residues from conserved active site bordering loops. Meropenem vimentin 2, pseudogene Homo sapiens