Title : Niclosamide enhances the cytotoxic effect of cisplatin in cisplatin-resistant human lung cancer cells via suppression of lung resistance-related protein and c-myc.

Pub. Date : 2018 Mar

PMID : 29257330






3 Functional Relationships(s)
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1 Niclosamide enhances the cytotoxic effect of cisplatin in cisplatin-resistant human lung cancer cells via suppression of lung resistance-related protein and c-myc. Niclosamide MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 The expression levels of cisplatin-resistant-associated molecules (lung resistance-related protein and c-myc) following niclosamide treatment in A549/DDP cells were evaluated by western blot analysis. Niclosamide MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 Furthermore, niclosamide decreased the expression level of c-myc protein, which may influence DDP sensitivity of A549/DDP cells. Niclosamide MYC proto-oncogene, bHLH transcription factor Homo sapiens