Title : COX-2 metabolic products, the prostaglandin I2 and F2α, mediate the effects of TNF-α and Zn2+ in stimulating the phosphorylation of Tau.

Pub. Date : 2017 Nov 21

PMID : 29245902






1 Functional Relationships(s)
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1 Using human TauP301S transgenic (Tg) mice as in vivo model, our results demonstrated that PGI2 and PGF2alpha mediated the effects of tumor necrosis factor alpha (TNF-alpha) and Zinc ions (Zn2+) on upregulating the phosphorylation of tau via the PI3-K/AKT, ERK1/2 and JNK/c-Jun signaling pathways. Dinoprost mitogen-activated protein kinase 3 Mus musculus