Pub. Date : 2018 Feb
PMID : 29242151
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, resveratrol-induced nuclear accumulation of COX-2 enhances p53-dependent anti-proliferation in different types of cancers. | Resveratrol | tumor protein p53 | Homo sapiens |
| 2 | Treatment with resveratrol leads to phosphorylation and nuclear translocation of mitogen-activated protein kinase (ERK1/2), and accumulation of nuclear COX-2 to complex with pERK1/2 and p53. | Resveratrol | tumor protein p53 | Homo sapiens |
| 3 | We investigated the mechanisms by which resveratrol-inducible COX-2 facilitates p53-dependent anti-proliferation in prostate cancer LNCaP cells. | Resveratrol | tumor protein p53 | Homo sapiens |
| 4 | Resveratrol treatment caused nuclear accumulation and complexing of ERK1/2, pSer15-p53 and COX-2 which was activated ERK1/2-dependent. | Resveratrol | tumor protein p53 | Homo sapiens |