Title : Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells.

Pub. Date : 2017 Nov

PMID : 29238104






2 Functional Relationships(s)
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1 The effects of IPA on IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 were studied using proximal tubular cells (HK-2). Indican cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
2 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. Indican cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus