Title : Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

Pub. Date : 2017 Dec 21

PMID : 29236692






1 Functional Relationships(s)
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1 We also present crystal structures of RAPTOR-TOS motif complexes that define the determinants of TOS recognition, of an mTOR FKBP12-rapamycin-binding (FRB) domain-substrate complex that establishes a second substrate-recruitment mechanism, and of a truncated mTOR-PRAS40 complex that reveals PRAS40 inhibits both substrate-recruitment sites. tos regulatory associated protein of MTOR complex 1 Homo sapiens