Title : The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus.

Pub. Date : 2019 Mar

PMID : 29228766






3 Functional Relationships(s)
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1 BACKGROUND/AIMS: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM). coenzyme Q10 MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus
2 The addition of CoQ10 to MET further improved hyperglycemia, decreased HOMA-R index, and increased plasma insulin concentration compared with the SRL group than MET alone therapy. coenzyme Q10 MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus
3 In addition, co-treatment of CoQ10 and MET significantly increased the levels of antiperoxidative enzymes in the pancreas islet cells compared with MET. coenzyme Q10 MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus