Title : Tumour necrosis factor-alpha in uraemic serum promotes osteoblastic transition and calcification of vascular smooth muscle cells via extracellular signal-regulated kinases and activator protein 1/c-FOS-mediated induction of interleukin 6 expression.

Pub. Date : 2018 Apr 1

PMID : 29228352






3 Functional Relationships(s)
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1 Exposure of VSMCs to uraemic serum or recombinant TNF-alpha lead to a strong upregulation of IL-6 mRNA expression and protein secretion, which was mediated by activator protein 1 (AP-1)/c-FOS-pathway signalling. vsmcs Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Exposure of VSMCs to uraemic serum or recombinant TNF-alpha lead to a strong upregulation of IL-6 mRNA expression and protein secretion, which was mediated by activator protein 1 (AP-1)/c-FOS-pathway signalling. vsmcs Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Exposure of VSMCs to uraemic serum or recombinant TNF-alpha lead to a strong upregulation of IL-6 mRNA expression and protein secretion, which was mediated by activator protein 1 (AP-1)/c-FOS-pathway signalling. vsmcs Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens