Title : Design, Synthesis, and Evaluation of GLUT Inhibitors.

Pub. Date : 2018

PMID : 29218520






1 Functional Relationships(s)
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1 This process started with the identification of a focused series of oxime derivatives, originally designed as estrogen receptor (ER) ligands, which were structurally optimized in order to direct their activity towards GLUT1 and to minimize their binding to the ERs, leading to the production of efficient and selective inhibitors of glucose uptake in cancer cells. Oximes solute carrier family 2 member 1 Homo sapiens