Pub. Date : 2018 Mar
PMID : 29217539
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats. | lorcaserin | 5-hydroxytryptamine receptor 2C | Homo sapiens |
| 2 | Lorcaserin is a serotonin (5-HT)2C receptor-preferring agonist approved by the US Food and Drug Administration to treat obesity. | lorcaserin | 5-hydroxytryptamine receptor 2C | Homo sapiens |
| 3 | Antagonism of 5-HT2C (but not 5-HT1A or 5-HT2A) receptors blocked the effects of lorcaserin on cocaine and MDPV self-administration. | lorcaserin | 5-hydroxytryptamine receptor 2C | Homo sapiens |
| 4 | Taken together, these data provide additional support for further development of 5-HT2C receptor agonists, such as lorcaserin, for the treatment of stimulant abuse. | lorcaserin | 5-hydroxytryptamine receptor 2C | Homo sapiens |