Pub. Date : 2017 Nov 7
PMID : 29212268
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | COMP-angiopoietin-1 mitigates changes in lipid droplet size, macrophage infiltration of adipose tissue and renal inflammation in streptozotocin-induced diabetic mice. | Streptozocin | angiopoietin 1 | Mus musculus |
| 2 | Our data showed that COMP-Ang1 increased the density of platelet endothelial cell adhesion molecule-1 (PECAM-1)-1-positive vascular endothelial cells in adipose tissue, which were significantly decreased by treatment with STZ. | Streptozocin | angiopoietin 1 | Mus musculus |
| 3 | COMP-Ang1 ameliorated the STZ-induced decrease in lipid droplet diameter and increase in macrophage infiltration in adipose tissue. | Streptozocin | angiopoietin 1 | Mus musculus |
| 4 | There was a beneficial effect on serum insulin levels after treatment with COMP-Ang1 in STZ-induced diabetic mice. | Streptozocin | angiopoietin 1 | Mus musculus |
| 5 | COMP-Ang1 was found to ameliorate the up-regulation of proinflammatory molecules and F4/80-positive macrophage infiltration in the kidneys of STZ-treated mice. | Streptozocin | angiopoietin 1 | Mus musculus |
| 6 | COMP-Ang1 increased the phosphorylation of Akt in epididymal adipose tissue and kidneys of STZ-induced diabetic mice. | Streptozocin | angiopoietin 1 | Mus musculus |
| 7 | These data indicate that COMP-Ang1 regulates lipogenic effects in adipose tissue and renal inflammation in STZ-induced diabetic mice. | Streptozocin | angiopoietin 1 | Mus musculus |