Pub. Date : 2017 Nov 7
PMID : 29212168
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells. | Iron | solute carrier family 40 member 1 | Homo sapiens |
| 2 | Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. | Iron | solute carrier family 40 member 1 | Homo sapiens |
| 3 | Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. | Iron | solute carrier family 40 member 1 | Homo sapiens |
| 4 | Overexpression of SLC40A1 was able to reverse cisplatin resistance induced by Nrf2, while knockdown of SLC40A1 restored cisplatin resistance and increased iron concentration. | Iron | solute carrier family 40 member 1 | Homo sapiens |
| 5 | Iron overload induced by SLC40A1 resulted in cisplatin resistance in ovarian cancer. | Iron | solute carrier family 40 member 1 | Homo sapiens |