Pub. Date : 2017
PMID : 29209219
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential Effects of Inhibitor Combinations on Lysophosphatidic Acid-Mediated Chemokine Secretion in Unprimed and Tumor Necrosis Factor-alpha-Primed Synovial Fibroblasts. | lysophosphatidic acid | tumor necrosis factor | Homo sapiens |
| 2 | RAFLS pretreated or not with TNFalpha were stimulated with LPA. | lysophosphatidic acid | tumor necrosis factor | Homo sapiens |
| 3 | Priming with TNFalpha enhanced LPA-mediated MSK phosphorylation and cytokine/chemokine production. | lysophosphatidic acid | tumor necrosis factor | Homo sapiens |
| 4 | In TNFalpha-primed RAFLS the super-production of IL-8 and IL-6 induced by LPA occurs mainly via MSK-independent pathways, and simultaneous inhibition of at least two MAPK signaling pathways was required to block their synthesis. | lysophosphatidic acid | tumor necrosis factor | Homo sapiens |
| 5 | Since simultaneous inhibition of both the p38MAPK and ERK-MSK-CREB pathways are required to significantly reduce LPA-mediated IL-8 and IL-6 production in TNFalpha-preconditioned RAFLS, drug combinations targeting these two pathways are potential new strategies to treat rheumatoid arthritis. | lysophosphatidic acid | tumor necrosis factor | Homo sapiens |