Title : A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.

Pub. Date : 2017 Dec 5

PMID : 29208967






1 Functional Relationships(s)
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1 A selective inhibitor, T-5224, significantly suppressed the interleukin-1beta-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription in human nucleus pulposus cells and in a mouse explant culture model of IVD degeneration. 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens