Title : NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB pathway, in phorbol 12-myristate 13-acetate-induced macrophages.

Pub. Date : 2018 Feb

PMID : 29207123






5 Functional Relationships(s)
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1 NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-kappaB pathway, in phorbol 12-myristate 13-acetate-induced macrophages. Tetradecanoylphorbol Acetate NLR family pyrin domain containing 3 Homo sapiens
2 The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome. Tetradecanoylphorbol Acetate NLR family pyrin domain containing 3 Homo sapiens
3 The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome. Tetradecanoylphorbol Acetate NLR family pyrin domain containing 3 Homo sapiens
4 The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages. Tetradecanoylphorbol Acetate NLR family pyrin domain containing 3 Homo sapiens
5 In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages. Tetradecanoylphorbol Acetate NLR family pyrin domain containing 3 Homo sapiens