Title : Anti-nociceptive effect of dexmedetomidine in a rat model of monoarthritis via suppression of the TLR4/NF-κB p65 pathway.

Pub. Date : 2017 Nov

PMID : 29201195






3 Functional Relationships(s)
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1 Anti-nociceptive effect of dexmedetomidine in a rat model of monoarthritis via suppression of the TLR4/NF-kappaB p65 pathway. Dexmedetomidine toll-like receptor 4 Rattus norvegicus
2 DEX treatment markedly reduced mechanical and thermal hyperalgesia, suppressed MA-induced elevation of the pro-inflammatory cytokines and inhibited the TLR4/NF-kappaB p65 pathway, while these effects were blocked by pre-treatment with the selective alpha2AR antagonist BRL44408 (15 microg) at 30 min prior to CFA injection. Dexmedetomidine toll-like receptor 4 Rattus norvegicus
3 These results suggested that DEX has an anti-nociceptive effect via suppressing the TLR4/NF-kappaB p65 pathway. Dexmedetomidine toll-like receptor 4 Rattus norvegicus