Pub. Date : 2017 Nov
PMID : 29201195
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Anti-nociceptive effect of dexmedetomidine in a rat model of monoarthritis via suppression of the TLR4/NF-kappaB p65 pathway. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
2 | DEX treatment markedly reduced mechanical and thermal hyperalgesia, suppressed MA-induced elevation of the pro-inflammatory cytokines and inhibited the TLR4/NF-kappaB p65 pathway, while these effects were blocked by pre-treatment with the selective alpha2AR antagonist BRL44408 (15 microg) at 30 min prior to CFA injection. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
3 | These results suggested that DEX has an anti-nociceptive effect via suppressing the TLR4/NF-kappaB p65 pathway. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |