Title : The role of phospholipase A2 in microsomal lipid peroxidation induced with t-butyl hydroperoxide.

Pub. Date : 1989 Feb 15

PMID : 2920033






4 Functional Relationships(s)
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1 When PlA2 was inhibited with chlorpromazine, mepacrine, or p-bromphenacyl bromide, the accumulation of thiobarbituric acid reactive substances (TBARS) was reduced in a dose dependent manner. Thiobarbituric Acid Reactive Substances phospholipase A2 group IB Rattus norvegicus
2 When PlA2 was inhibited with chlorpromazine, mepacrine, or p-bromphenacyl bromide, the accumulation of thiobarbituric acid reactive substances (TBARS) was reduced in a dose dependent manner. Thiobarbituric Acid Reactive Substances phospholipase A2 group IB Rattus norvegicus
3 When endogenous PlA2 was activated with mellitin prior to induction of peroxidation, accumulation of both TBARS and dienes was reduced. Thiobarbituric Acid Reactive Substances phospholipase A2 group IB Rattus norvegicus
4 Analogously, pretreatment with exogenous PlA2 reduced both dienes and TBARS. Thiobarbituric Acid Reactive Substances phospholipase A2 group IB Rattus norvegicus