Pub. Date : 2017 Nov 3
PMID : 29190892
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 2 | In the present study, we investigated the role and molecular mechanism of H19 lncRNA in chemoresistance development by using doxorubicin (Dox) resistance in breast cancer cells as a model system. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 3 | In the present study, we investigated the role and molecular mechanism of H19 lncRNA in chemoresistance development by using doxorubicin (Dox) resistance in breast cancer cells as a model system. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 4 | H19 lncRNA expression was significantly increased in anthracycline-treated and Dox-resistant MCF-7 breast cancer cells. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 5 | This H19 overexpression was contributed to cancer cell resistance to anthracyclines and paclitaxel as knockdown of H19 lncRNA by a specific H19 shRNA in Dox-resistant cells significantly improved the cell sensitivity to anthracyclines and paclitaxel. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 6 | This H19 overexpression was contributed to cancer cell resistance to anthracyclines and paclitaxel as knockdown of H19 lncRNA by a specific H19 shRNA in Dox-resistant cells significantly improved the cell sensitivity to anthracyclines and paclitaxel. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 7 | This H19 overexpression was contributed to cancer cell resistance to anthracyclines and paclitaxel as knockdown of H19 lncRNA by a specific H19 shRNA in Dox-resistant cells significantly improved the cell sensitivity to anthracyclines and paclitaxel. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 8 | Furthermore, gene expression profiling analysis revealed that a total of 192 genes were associated with H19-mediated Dox resistance. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 9 | Using genetic and pharmacological approaches, we demonstrated that MDR1 and MRP4 were major effectors of H19-regulated Dox resistance in breast cancer cells as MDR1 and MRP4 expression was markedly elevated in Dox-resistant cells while dramatically reduced when H19 was knocked down. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 10 | Using genetic and pharmacological approaches, we demonstrated that MDR1 and MRP4 were major effectors of H19-regulated Dox resistance in breast cancer cells as MDR1 and MRP4 expression was markedly elevated in Dox-resistant cells while dramatically reduced when H19 was knocked down. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 11 | Using genetic and pharmacological approaches, we demonstrated that MDR1 and MRP4 were major effectors of H19-regulated Dox resistance in breast cancer cells as MDR1 and MRP4 expression was markedly elevated in Dox-resistant cells while dramatically reduced when H19 was knocked down. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 12 | Using genetic and pharmacological approaches, we demonstrated that MDR1 and MRP4 were major effectors of H19-regulated Dox resistance in breast cancer cells as MDR1 and MRP4 expression was markedly elevated in Dox-resistant cells while dramatically reduced when H19 was knocked down. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |