Pub. Date : 2017 Dec 19
PMID : 29185343
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1alpha Signaling Pathway. | PQQ Cofactor | sirtuin 1 | Mus musculus |
| 2 | Moreover, we observed that PQQ treatment induces deacetylation of the peroxisome proliferator-activated receptor-gamma-coactivator 1alpha (PGC-1alpha) and facilitates its nuclear translocation and target gene expression but does not affect its protein levels, implying increased activity of the NAD+-dependent protein deacetylase sirtuin 1 (SIRT1). | PQQ Cofactor | sirtuin 1 | Mus musculus |
| 3 | Moreover, we observed that PQQ treatment induces deacetylation of the peroxisome proliferator-activated receptor-gamma-coactivator 1alpha (PGC-1alpha) and facilitates its nuclear translocation and target gene expression but does not affect its protein levels, implying increased activity of the NAD+-dependent protein deacetylase sirtuin 1 (SIRT1). | PQQ Cofactor | sirtuin 1 | Mus musculus |
| 4 | Indeed, treatment with a SIRT1 selective inhibitor, EX-527, hampered the ability of PQQ to stimulate PGC-1alpha-mediated mitochondrial biogenesis. | PQQ Cofactor | sirtuin 1 | Mus musculus |
| 5 | Our results suggest that PQQ-inducible mitochondrial biogenesis can be attributed to activation of the SIRT1/PGC-1alpha signaling pathway by enhancing cellular NAD+ formation. | PQQ Cofactor | sirtuin 1 | Mus musculus |