Title : UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids.

Pub. Date : 2018 Jan 5

PMID : 29167270






2 Functional Relationships(s)
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Protein Name
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1 UBIAD1 (UbiA prenyltransferase domain-containing protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2 We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)-localized 3-hydroxy-3-methylglutaryl (HMG) CoA reductase. geranylgeranyl pyrophosphate 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 UBIAD1 (UbiA prenyltransferase domain-containing protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2 We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)-localized 3-hydroxy-3-methylglutaryl (HMG) CoA reductase. geranylgeranyl pyrophosphate 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens