Title : DT-13 ameliorates TNF-α-induced nitric oxide production in the endothelium in vivo and in vitro.

Pub. Date : 2018 Jan 1

PMID : 29162452






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 DT-13 ameliorates TNF-alpha-induced nitric oxide production in the endothelium in vivo and in vitro. Nitric Oxide tumor necrosis factor Homo sapiens
2 This study aimed to explore the protective effect of DT-13 on endothelium through regulating of nitric oxide production induced by Tumor necrosis factor-alpha (TNF-alpha). Nitric Oxide tumor necrosis factor Homo sapiens
3 This study aimed to explore the protective effect of DT-13 on endothelium through regulating of nitric oxide production induced by Tumor necrosis factor-alpha (TNF-alpha). Nitric Oxide tumor necrosis factor Homo sapiens
4 Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA. Nitric Oxide tumor necrosis factor Homo sapiens
5 Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA. Nitric Oxide tumor necrosis factor Homo sapiens