Title : Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway.

Pub. Date : 2018 Jan

PMID : 29156516






2 Functional Relationships(s)
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Protein Name
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1 Sorafenib, a multikinase inhibitor for hepatocellular carcinoma treatment, inhibits the Raf/MAPK/ERK signaling pathway. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
2 However, PI3K/Akt signaling pathway is activated by Sorafenib and cross-talks with the Raf/MAPK/ERK signaling pathway, leading to drug resistance. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens