Title : Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1.

Pub. Date : 2017 Dec 15

PMID : 29153737






4 Functional Relationships(s)
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1 With regard to the QR1 induction activity, 11 exhibited the highest QR1 induction ratio (IR) with a low concentration to double activity (CD) value (IR = 8.34, CD = 2.75 muM), while 7 showed the most potent CD value of 1.12 muM. Cadmium NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 With regard to the QR1 induction activity, 11 exhibited the highest QR1 induction ratio (IR) with a low concentration to double activity (CD) value (IR = 8.34, CD = 2.75 muM), while 7 showed the most potent CD value of 1.12 muM. Cadmium NAD(P)H quinone dehydrogenase 1 Homo sapiens
3 With regard to the QR1 induction activity, 11 exhibited the highest QR1 induction ratio (IR) with a low concentration to double activity (CD) value (IR = 8.34, CD = 2.75 muM), while 7 showed the most potent CD value of 1.12 muM. Cadmium NAD(P)H quinone dehydrogenase 1 Homo sapiens
4 With regard to the QR1 induction activity, 11 exhibited the highest QR1 induction ratio (IR) with a low concentration to double activity (CD) value (IR = 8.34, CD = 2.75 muM), while 7 showed the most potent CD value of 1.12 muM. Cadmium NAD(P)H quinone dehydrogenase 1 Homo sapiens