Title : Melatonin inhibits colon cancer RKO cell migration by downregulating Rho‑associated protein kinase expression via the p38/MAPK signaling pathway.

Pub. Date : 2017 Dec

PMID : 29152648






2 Functional Relationships(s)
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1 The results revealed that the expression levels of ROCK2, p-MYPT1 and p-MLC in RKO cells were decreased, and the membrane protein expression of ZO-1 and occludin increased when the cells were treated with melatonin. Melatonin Rho associated coiled-coil containing protein kinase 2 Homo sapiens
2 qPCR demonstrated that melatonin downregulated ROCK2 gene expression, and upregulated the expression of the ZO-1 and occludin genes. Melatonin Rho associated coiled-coil containing protein kinase 2 Homo sapiens