Title : GABAB receptors in neocortical and hippocampal pyramidal neurons are coupled to different potassium channels.

Pub. Date : 2017 Dec

PMID : 29131436






3 Functional Relationships(s)
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1 Bath application of the non-specific GIRK channel blocker barium (200 mum) abolished outward currents evoked by GABAB receptors in CA1 pyramidal, but only partially blocked GABAB responses in layer 5 neurons. gabab carbonic anhydrase 1 Rattus norvegicus
2 Tertiapin-Q partially blocked GABAB responses in CA1 pyramidal neurons, but was ineffective in blocking GABAB responses in neocortical layer 5 neurons. gabab carbonic anhydrase 1 Rattus norvegicus
3 Consistent with the idea that GABAB receptors are coupled to two-pore domain potassium channels, the non-specific blockers quinidine and bupivacaine partially blocked GABAB responses in both layer 5 and CA1 neurons. gabab carbonic anhydrase 1 Rattus norvegicus