Title : Optimization of pharmacokinetic properties by modification of a carbazole-based cannabinoid receptor subtype 2 (CB2) ligand.

Pub. Date : 2018 Jan 1

PMID : 29126730






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Compared with the fluoroethyl derivative 1a, the carbazole N-atom of the fluoroisopropyl derivative 13a (Ki(CB2) = 2.9 nM) is better shielded against the attack of CYP enzymes as formation of N-oxides was not observed and N-dealkylation took place to a less amount. n-oxides cannabinoid receptor 2 (macrophage) Mus musculus