Title : A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer.

Pub. Date : 2017 Nov 9

PMID : 29123088

2 Functional Relationships(s)
Compound Name
Protein Name
1 By connecting a tumor-targeting nucleolin aptamer (NucA) to the active hydroxyl group at 2" position of PTX via a cathepsin B sensitive dipeptide bond, NucA-PTX remains stable and inactive in the circulation. Dipeptides cathepsin B Homo sapiens
2 Once inside cells, the dipeptide bond linker of NucA-PTX is cleaved by cathepsin B and then the conjugated PTX is released for action. Dipeptides cathepsin B Homo sapiens