Pub. Date : 2017 Nov 9
PMID : 29123088
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By connecting a tumor-targeting nucleolin aptamer (NucA) to the active hydroxyl group at 2" position of PTX via a cathepsin B sensitive dipeptide bond, NucA-PTX remains stable and inactive in the circulation. | Dipeptides | cathepsin B | Homo sapiens |
| 2 | Once inside cells, the dipeptide bond linker of NucA-PTX is cleaved by cathepsin B and then the conjugated PTX is released for action. | Dipeptides | cathepsin B | Homo sapiens |