Pub. Date : 2018 Jan
PMID : 29112787
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dabrafenib inhibits the growth of BRAF-WT cancers through CDK16 and NEK9 inhibition. | dabrafenib | cyclin dependent kinase 16 | Homo sapiens |
| 2 | Using mass spectrometry-based chemical proteomics, we identified NEK9 and CDK16 as unique targets of dabrafenib. | dabrafenib | cyclin dependent kinase 16 | Homo sapiens |
| 3 | In summary, we have identified dabrafenib as a potent inhibitor of NEK9 and CDK16, and our studies suggest that inhibition of these kinases may have activity against cancers that do not harbor BRAF mutations. | dabrafenib | cyclin dependent kinase 16 | Homo sapiens |