Pub. Date : 2017 Nov 6
PMID : 29109438
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition. | Reactive Oxygen Species | signal transducer and activator of transcription 3 | Mus musculus |