Title : A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions.

Pub. Date : 2018 Jan

PMID : 29109127






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism. Folic Acid DNA polymerase gamma, catalytic subunit Homo sapiens
2 The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism. Folic Acid DNA polymerase gamma, catalytic subunit Homo sapiens