Title : Interaction of heparin with human basic fibroblast growth factor: protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan.

Pub. Date : 1989 Jan

PMID : 2910884






12 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Interaction of heparin with human basic fibroblast growth factor: protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan. Heparin fibroblast growth factor 2 Homo sapiens
2 Fibroblast growth factors (FGF) are a family of heparin-binding angiogenic polypeptide mitogens. Heparin fibroblast growth factor 2 Homo sapiens
3 In the presence of heparin, recombinant human basic fibroblast growth factor (bFGF) is fully protected from tryptic digestion and partially protected from chymotryptic digestion. Heparin fibroblast growth factor 2 Homo sapiens
4 In the presence of heparin, recombinant human basic fibroblast growth factor (bFGF) is fully protected from tryptic digestion and partially protected from chymotryptic digestion. Heparin fibroblast growth factor 2 Homo sapiens
5 Complete protection of bFGF by heparin is achieved at ratios of growth factor:heparin of approximately 10 or less (w/w). Heparin fibroblast growth factor 2 Homo sapiens
6 The protection requires bioactive bFGF because inactivated bFGF is rapidly degraded by trypsin or chymotrypsin in the presence of heparin. Heparin fibroblast growth factor 2 Homo sapiens
7 The protection requires bioactive bFGF because inactivated bFGF is rapidly degraded by trypsin or chymotrypsin in the presence of heparin. Heparin fibroblast growth factor 2 Homo sapiens
8 The bFGF-heparin interaction forms hydrophobic complexes which become insoluble in aqueous buffers at bFGF:heparin ratios of 8 to 10 (w/w). Heparin fibroblast growth factor 2 Homo sapiens
9 The bFGF-heparin interaction forms hydrophobic complexes which become insoluble in aqueous buffers at bFGF:heparin ratios of 8 to 10 (w/w). Heparin fibroblast growth factor 2 Homo sapiens
10 The bFGF-heparin interaction forms hydrophobic complexes which become insoluble in aqueous buffers at bFGF:heparin ratios of 8 to 10 (w/w). Heparin fibroblast growth factor 2 Homo sapiens
11 The heparin was found to bind up to a tenfold excess of bFGF on a weight basis. Heparin fibroblast growth factor 2 Homo sapiens
12 bFGF in the presence of heparin is as active as bFGF alone in inducing 3H-thymidine incorporation into Swiss 3T3 fibroblast DNA. Heparin fibroblast growth factor 2 Homo sapiens