Title : Punica granatum L. Fruit Aqueous Extract Suppresses Reactive Oxygen Species-Mediated p53/p65/miR-145 Expressions followed by Elevated Levels of irs-1 in Alloxan-Diabetic Rats.

Pub. Date : 2018 Jan

PMID : 29105385






2 Functional Relationships(s)
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1 This study examines the effects of pomegranate fruit aqueous extract (PGE) on the levels of ROS, p53, p65, miR-145, and its target insulin receptor substrate 1 (irs-1) mRNA in Alloxan-diabetic male Wistar rats. phenylglycidyl ether Wistar clone pR53P1 p53 pseudogene Rattus norvegicus
2 CONCLUSIONS: PGE administration downregulated miR-145 levels in Alloxan-diabetic Wistar rats by suppression of ROS-mediated p53 and p65 overexpression. phenylglycidyl ether Wistar clone pR53P1 p53 pseudogene Rattus norvegicus