Title : Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients.

Pub. Date : 2018 Jan

PMID : 29100034






2 Functional Relationships(s)
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1 However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3. dapt negative elongation factor complex member C/D Homo sapiens
2 In conclusion, our results suggest that blocking Notch signaling by DAPT could inhibit Th2 responses and restore Th1/Th2 imbalance in TB patients. dapt negative elongation factor complex member C/D Homo sapiens