Title : Exenatide upregulates gene expression of glucagon-like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice.

Pub. Date : 2018 Apr

PMID : 29091313






6 Functional Relationships(s)
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1 Exenatide upregulates gene expression of glucagon-like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice. Exenatide glucagon-like peptide 1 receptor Mus musculus
2 Exenatide, a potent and selective agonist for the GLP-1 receptor, is currently approved for the treatment of type 2 diabetes mellitus. Exenatide glucagon-like peptide 1 receptor Mus musculus
3 The aim of this study was to assess the effect of chronic exenatide treatment on the hippocampal gene expression levels of GLP-1 receptor and NGF in diabetic mice. Exenatide glucagon-like peptide 1 receptor Mus musculus
4 The effects of chronic exenatide treatment (0.1 mug/kg, s.c., twice daily for 2 weeks) on GLP-1 receptor and NGF gene expression levels in the hippocampus of streptozotocin/nicotinamide (STZ-NA)-induced diabetic mice were assessed by quantitative real-time polymerase chain reaction (RT-PCR). Exenatide glucagon-like peptide 1 receptor Mus musculus
5 Importantly, a significant increase in the gene expression level of GLP-1 receptor and NGF was determined after 2 weeks of exenatide administration. Exenatide glucagon-like peptide 1 receptor Mus musculus
6 Increased gene expression level of GLP-1 receptor and NGF may underlie the beneficial action of exenatide in STZ/NA-induced diabetes. Exenatide glucagon-like peptide 1 receptor Mus musculus