Pub. Date : 2017 Sep 26
PMID : 29088724
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of angiogenesis by arsenic trioxide via TSP-1-TGF-beta1-CTGF-VEGF functional module in rheumatoid arthritis. | Arsenic Trioxide | vascular endothelial growth factor A | Homo sapiens |
| 2 | We show that As2O3 inhibits angiogenesis in the collagen-induced arthritis (CIA) synovium and consequently arthritis severity via significant suppression of TSP-1, TGF-beta1, CTGF and VEGF expression in the CIA synovium, plus in the RA-FLS and HDMECs co-culture as well as NH-FLS and HDMECs co-culture system along with the presence or absence of TNF-alpha treatment. | Arsenic Trioxide | vascular endothelial growth factor A | Homo sapiens |
| 3 | Thus As2O3 has a significant anti-angiogenesis effect on the RA-FLS and CIA synovium via its inhibition of the RA angiogenic functional module of TSP-1, TGF-beta1, CTGF and VEGF and may have a potential for treating RA beyond cancer therapy. | Arsenic Trioxide | vascular endothelial growth factor A | Homo sapiens |