Title : Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge.

Pub. Date : 2017

PMID : 29085809






2 Functional Relationships(s)
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1 immunization with MCS-DNA induced a modest peptide-specific Th1(IFN-gamma, TNF-alpha, and IL-2) response in the spleen, while a potent poly-functional CD4+ T response that largely produced TNF-alpha and IFN-gamma, as well as IL-2 in the lung, qualitatively better than that induced by CS-DNA and BCG vaccination. mcs tumor necrosis factor Homo sapiens
2 immunization with MCS-DNA induced a modest peptide-specific Th1(IFN-gamma, TNF-alpha, and IL-2) response in the spleen, while a potent poly-functional CD4+ T response that largely produced TNF-alpha and IFN-gamma, as well as IL-2 in the lung, qualitatively better than that induced by CS-DNA and BCG vaccination. mcs tumor necrosis factor Homo sapiens