Title : 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice.

Pub. Date : 2017 Oct 27

PMID : 29075038






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1 Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs. protopanaxadiol AKT serine/threonine kinase 1 Homo sapiens