Pub. Date : 1988 Dec
PMID : 2907482
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of vimentin synthesis in a murine myeloma cell line by TPA is strongly dependent on the composition of the cell culture medium. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 2 | MPC-11 mouse plasmacytoma cells virtually lacking intermediate filament (IF) proteins can be induced to synthesize and accumulate the IF protein vimentin by treatment with the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 3 | MPC-11 mouse plasmacytoma cells virtually lacking intermediate filament (IF) proteins can be induced to synthesize and accumulate the IF protein vimentin by treatment with the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 4 | Vimentin synthesis could be elicited by a TPA concentration as low as 10(-9) M in cells grown in HB-102 serum-free medium. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 5 | After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 6 | After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 7 | After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 8 | This suppression seems to be due, at least in part, to nondialyzable, heat-sensitive components of FCS, since the dialyzable fraction even enhanced vimentin induction by TPA. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 9 | When cells grown in the presence of FCS were transferred back to serum-free medium, their ability to synthesize vimentin in response to TPA treatment was readily restored. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |
| 10 | The individual components of serum-free medium which proved to support vimentin induction by TPA were insulin and the unsaturated fatty acids oleic acid and linoleic acid. | Tetradecanoylphorbol Acetate | vimentin | Mus musculus |