Title : Cell lines generated from a chronic lymphocytic leukemia mouse model exhibit constitutive Btk and Akt signaling.

Pub. Date : 2017 Sep 22

PMID : 29069762






1 Functional Relationships(s)
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1 Treatment of the cell lines with small molecule inhibitors specific for Btk (ibrutinib) or PI3K (idelalisib), which is upstream of Akt, resulted in reduced viability, proliferation and fibronectin-dependent cell adhesion. idelalisib thymoma viral proto-oncogene 1 Mus musculus