Title : Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation.

Pub. Date : 2018 Jan

PMID : 29069608






1 Functional Relationships(s)
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1 Extensive studies have explored the mechanisms regulating this signaling cascade, and identified an E2 complex, Uev1A-Ubc13, that mediates K63-linked poly-Ub chain formation and thus recruits NEMO to activate the signaling transduction. poly-ub ubiquitin conjugating enzyme E2 N Homo sapiens