Title : Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice.

Pub. Date : 2018 Jan 1

PMID : 29069304






2 Functional Relationships(s)
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1 Targeted extracellular recordings were used to record firing activity from green fluorescent protein-identified GnRH neurons in brain slices before and during CRH treatment; recordings were done in the afternoon when estradiol has a positive feedback effect to increase GnRH neuron firing. Estradiol gonadotropin releasing hormone 1 Mus musculus
2 These results indicate that CRH alters GnRH neuron activity and that estradiol is required for CRH to exert both stimulatory and inhibitory effects on GnRH neurons. Estradiol gonadotropin releasing hormone 1 Mus musculus