Title : Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation.

Pub. Date : 2018 Jan 12

PMID : 29069290






4 Functional Relationships(s)
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1 Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6 and IL-1beta. celastrol nitric oxide synthase 2, inducible Mus musculus
2 Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6 and IL-1beta. celastrol nitric oxide synthase 2, inducible Mus musculus
3 Celastrol chemoprevention of CAC in this new model of intestinal neoplasia was associated with significant suppression of iNOS at 4 months of age, and iNOS, COX-2 and NFkappaB at 6 months of age, with significant reduction in inflammatory cytokines, IL-6 and IL-1beta. celastrol nitric oxide synthase 2, inducible Mus musculus
4 Celastrol chemoprevention of CAC in this new model of intestinal neoplasia was associated with significant suppression of iNOS at 4 months of age, and iNOS, COX-2 and NFkappaB at 6 months of age, with significant reduction in inflammatory cytokines, IL-6 and IL-1beta. celastrol nitric oxide synthase 2, inducible Mus musculus