Title : α-Linolenic Acid Inhibits Receptor Activator of NF-κB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-κB-iNOS) Signaling Pathways.

Pub. Date : 2017 Oct 24

PMID : 29061958






3 Functional Relationships(s)
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1 alpha-Linolenic Acid Inhibits Receptor Activator of NF-kappaB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-kappaB-iNOS) Signaling Pathways. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus
2 ALA (100 and 300 mg/kg) intervention to estrogen-deficiency induced bone loss mice (ovariectomized) showed reductions in TRAP+ osteoclasts count, CTX-I expression, levels of IL-1beta, IL-2, IL-6, IL10, TNF-alpha and MCP-1 and iNOS and COX-2. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus
3 CONCLUSIONS ALA suppresses RANKL-induced osteoclast differentiation and prevents inflammatory bone loss via downregulation of NF-kappaB-iNOS-COX-2 signaling. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus