Pub. Date : 2017 Dec 12
PMID : 29060932
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-34a increases cisplatin sensitivity of osteosarcoma cells in vitro through up-regulation of c-Myc and Bim signal. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | RESULTS: Treatment of U2OS cells with cisplatin induced cell apoptosis by upregulation of c-Myc -dependent Bim expression; Osteosarcoma U2OS cells transfected with miR-34a mimics (miR-34a/U2OS) induced cell apoptosis and inhibited cell survival, and increased the sensitivity of U2OS cells to cisplatin. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | CONCLUSIONS: Our data indicated that miR-34a enhanced the sensitivity to cisplatin by upregulation of c-Myc and Bim pathway. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |