Title : Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.

Pub. Date : 2017 Oct 20

PMID : 29057925






1 Functional Relationships(s)
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Protein Name
Organism
1 Addition of 2-HG to glioblastoma cultures recapitulates the effects of the IDH mutation on intrinsic apoptosis, shuts down oxidative phosphorylation and reduces ATP levels in glioblastoma cells. Adenosine Triphosphate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens